Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including astrocytes; strongest in distal convoluted tubule cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 12459
Sealed predictions
- MFHAS1 in dopamine neurons, braak-0.85 (p 0.004) → -0.37 (p 0.334)receipt 12468
- MFHAS1 in astrocytes, braak+0.16 (p 0.689) → +0.51 (p 0.163)receipt 12467
Swarm cases
receipt 12468: MFHAS1 in dopamine neurons, braak
- power
- full sample -0.55 (p 0.018, n 18), 95% CI -0.81 to -0.11. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.49 (p 0.037, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.49 (p 0.040, n 18). not the mix.
- skeptic
- leave-one-out range -0.73 to -0.50, sign flips 0; without severely affected donors -0.55 (p 0.018, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MFHAS1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 12467: MFHAS1 in astrocytes, braak
- power
- full sample +0.36 (p 0.148, n 18), 95% CI -0.13 to +0.71. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.34 (p 0.167, n 18). does not hold up.
- composition
- astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.32 (p 0.194, n 18). could be the mix.
- skeptic
- leave-one-out range +0.28 to +0.52, sign flips 0; without severely affected donors +0.36 (p 0.148, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MFHAS1 in astrocytes.
case closed: nothing better to follow up.
Receipts
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