parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.07 (overall 0.24)	0.07
cell type Human Protein Atlas	cell type enhanced in oligodendrocytes (1846 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 104	0.85
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 1784

receipt 1792: MAP7 in dopamine neurons, braak

power: full sample -0.00 (p 0.990, n 18), 95% CI -0.47 to +0.46. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.02 (p 0.928, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.00 (p 0.997, n 18). could be the mix.
skeptic: leave-one-out range -0.13 to +0.12, sign flips 10; without severely affected donors -0.00 (p 0.990, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for MAP7 in dopamine neurons.

case closed: nothing better to follow up.

receipt 1791: MAP7 in oligodendrocytes, braak

power: full sample +0.29 (p 0.246, n 18), 95% CI -0.21 to +0.67. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.26 (p 0.302, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.55 (p 0.017, n 18). not the mix.
skeptic: leave-one-out range +0.19 to +0.41, sign flips 0; without severely affected donors +0.29 (p 0.246, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for MAP7 in oligodendrocytes.

case closed: nothing better to follow up.

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