Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 30 Parkinson's papers of 9,839 | 0.55 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 11965
Sealed predictions
- MAL in dopamine neurons, braak+0.44 (p 0.235) → +0.20 (p 0.613)receipt 11974
Swarm cases
receipt 11974: MAL in dopamine neurons, braak
- power
- full sample +0.39 (p 0.111, n 18), 95% CI -0.10 to +0.72. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.34 (p 0.164, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.42 (p 0.082, n 18). could be the mix.
- skeptic
- leave-one-out range +0.31 to +0.55, sign flips 0; without severely affected donors +0.39 (p 0.111, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MAL in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts