parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in late spermatids	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 127	0.91
pathways Reactome	6 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 10142

MAD1L1 in microglia, braak-0.33 (p 0.386) → -0.26 (p 0.504)receipt 10147
MAD1L1 in dopamine neurons, braak-0.33 (p 0.383) → -0.52 (p 0.150)receipt 10148

receipt 10148: MAD1L1 in dopamine neurons, braak

power: full sample -0.24 (p 0.328, n 18), 95% CI -0.64 to +0.25. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.24 (p 0.328, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.34 (p 0.164, n 18). could be the mix.
skeptic: leave-one-out range -0.34 to -0.15, sign flips 0; without severely affected donors -0.24 (p 0.328, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for MAD1L1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 10147: MAD1L1 in microglia, braak

power: full sample -0.27 (p 0.273, n 18), 95% CI -0.66 to +0.22. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.23 (p 0.360, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.35 (p 0.150, n 18). could be the mix.
skeptic: leave-one-out range -0.44 to -0.18, sign flips 0; without severely affected donors -0.27 (p 0.273, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for MAD1L1 in microglia.

case closed: nothing better to follow up.

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