parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in astrocytes (8317 nCPM)	1.00
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 124	0.82
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 12754

LSAMP in astrocytes, braak-0.11 (p 0.787) → +0.13 (p 0.735)receipt 12760
LSAMP in dopamine neurons, braak+0.63 (p 0.067) → -0.11 (p 0.787)receipt 12761

receipt 12761: LSAMP in dopamine neurons, braak

power: full sample +0.26 (p 0.298, n 18), 95% CI -0.24 to +0.65. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.25 (p 0.319, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.31 (p 0.204, n 18). could be the mix.
skeptic: leave-one-out range +0.20 to +0.45, sign flips 0; without severely affected donors +0.26 (p 0.298, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LSAMP in dopamine neurons.

case closed: nothing better to follow up.

receipt 12760: LSAMP in astrocytes, braak

power: full sample +0.02 (p 0.935, n 18), 95% CI -0.45 to +0.48. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.01 (p 0.983, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.06 (p 0.827, n 18). could be the mix.
skeptic: leave-one-out range -0.10 to +0.14, sign flips 6; without severely affected donors +0.02 (p 0.935, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LSAMP in astrocytes.

case closed: nothing better to follow up.

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