Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in neutrophils | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 16214
Sealed predictions
- LPGAT1 in oligodendrocytes, braak+0.26 (p 0.493) → +0.05 (p 0.893)receipt 16221
- LPGAT1 in dopamine neurons, braak-0.14 (p 0.718) → -0.26 (p 0.493)receipt 16222
Swarm cases
receipt 16222: LPGAT1 in dopamine neurons, braak
- power
- full sample -0.15 (p 0.546, n 18), 95% CI -0.58 to +0.34. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.18 (p 0.482, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.19 (p 0.455, n 18). could be the mix.
- skeptic
- leave-one-out range -0.30 to -0.06, sign flips 0; without severely affected donors -0.15 (p 0.546, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LPGAT1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 16221: LPGAT1 in oligodendrocytes, braak
- power
- full sample +0.12 (p 0.627, n 18), 95% CI -0.36 to +0.56. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.14 (p 0.573, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.27 (p 0.277, n 18). could be the mix.
- skeptic
- leave-one-out range +0.01 to +0.24, sign flips 0; without severely affected donors +0.12 (p 0.627, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LPGAT1 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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