parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in leydig cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 51	0.91
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 15523

LPAR4 in dopamine neurons, braak-0.26 (p 0.493) → +0.69 (p 0.042)receipt 15531
LPAR4 in astrocytes, braak-0.24 (p 0.529) → +0.23 (p 0.549)receipt 15530

receipt 15531: LPAR4 in dopamine neurons, braak

power: full sample +0.19 (p 0.439, n 18), 95% CI -0.30 to +0.61. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.43 (p 0.079, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.34 (p 0.167, n 18). could be the mix.
skeptic: leave-one-out range +0.08 to +0.37, sign flips 0; without severely affected donors +0.19 (p 0.439, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LPAR4 in dopamine neurons.

case closed: nothing better to follow up.

receipt 15530: LPAR4 in astrocytes, braak

power: full sample +0.14 (p 0.591, n 18), 95% CI -0.35 to +0.57. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.14 (p 0.573, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.23 (p 0.351, n 18). could be the mix.
skeptic: leave-one-out range +0.03 to +0.26, sign flips 0; without severely affected donors +0.14 (p 0.591, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LPAR4 in astrocytes.

case closed: nothing better to follow up.

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