Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in oligodendrocytes (22 nCPM) | 1.00 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 5256
Sealed predictions
- LLGL1 in oligodendrocytes, braak-0.89 (p 0.001) → -0.61 (p 0.084)receipt 5262
- LLGL1 in dopamine neurons, braak-0.11 (p 0.778) → -0.27 (p 0.476)receipt 5263
Swarm cases
receipt 5263: LLGL1 in dopamine neurons, braak
- power
- full sample -0.34 (p 0.170, n 18), 95% CI -0.70 to +0.15. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.35 (p 0.156, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.36 (p 0.137, n 18). could be the mix.
- skeptic
- leave-one-out range -0.48 to -0.27, sign flips 0; without severely affected donors -0.34 (p 0.170, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LLGL1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 5262: LLGL1 in oligodendrocytes, braak
- power
- full sample -0.53 (p 0.023, n 18), 95% CI -0.80 to -0.09. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.55 (p 0.017, n 18). holds up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.58 (p 0.013, n 18). not the mix.
- skeptic
- leave-one-out range -0.66 to -0.47, sign flips 0; without severely affected donors -0.53 (p 0.023, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LLGL1 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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