parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including oligodendrocytes; strongest in kupffer cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	3 Parkinson's trials, 0 stopped	1.00
literature PubMed	9 Parkinson's papers of 1,992	0.70
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 15292

receipt 15301: LIPA in dopamine neurons, braak

power: full sample +0.14 (p 0.591, n 18), 95% CI -0.35 to +0.57. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.14 (p 0.591, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.23 (p 0.369, n 18). could be the mix.
skeptic: leave-one-out range +0.05 to +0.31, sign flips 0; without severely affected donors +0.14 (p 0.591, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LIPA in dopamine neurons.

case closed: nothing better to follow up.

receipt 15300: LIPA in oligodendrocytes, braak

power: full sample +0.30 (p 0.228, n 18), 95% CI -0.20 to +0.67. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.26 (p 0.294, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.32 (p 0.194, n 18). could be the mix.
skeptic: leave-one-out range +0.20 to +0.47, sign flips 0; without severely affected donors +0.30 (p 0.228, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LIPA in oligodendrocytes.

case closed: nothing better to follow up.

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