Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched, including oligodendrocytes; strongest in myonuclei | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 5482
Sealed predictions
- LDB3 in oligodendrocytes, braak-0.34 (p 0.375) → +0.02 (p 0.964)receipt 5488
- LDB3 in dopamine neurons, braak+0.05 (p 0.907) → -0.76 (p 0.017)receipt 5489
Swarm cases
receipt 5489: LDB3 in dopamine neurons, braak
- power
- full sample -0.39 (p 0.109, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.47 (p 0.047, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.55 (p 0.017, n 18). not the mix.
- skeptic
- leave-one-out range -0.53 to -0.30, sign flips 0; without severely affected donors -0.39 (p 0.109, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LDB3 in dopamine neurons.
case closed: nothing better to follow up.
receipt 5488: LDB3 in oligodendrocytes, braak
- power
- full sample -0.19 (p 0.450, n 18), 95% CI -0.60 to +0.30. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.16 (p 0.515, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.22 (p 0.384, n 18). could be the mix.
- skeptic
- leave-one-out range -0.37 to -0.12, sign flips 0; without severely affected donors -0.19 (p 0.450, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LDB3 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
loading the receipts