parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.08 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including oligodendrocyte progenitor cells; strongest in cardiomyocytes	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	114 Parkinson's trials, 8 stopped	0.87
literature PubMed	4 Parkinson's papers of 2,021	0.79
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 3473

receipt 3480: KY in dopamine neurons, braak

power: full sample -0.50 (p 0.035, n 18), 95% CI -0.78 to -0.04. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: -0.47 (p 0.049, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.52 (p 0.027, n 18). not the mix.
skeptic: leave-one-out range -0.68 to -0.44, sign flips 0; without severely affected donors -0.50 (p 0.035, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for KY in dopamine neurons.

case closed: nothing better to follow up.

receipt 3479: KY in oligodendrocytes, braak

power: full sample -0.37 (p 0.127, n 18), 95% CI -0.72 to +0.11. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.37 (p 0.127, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.34 (p 0.173, n 18). could be the mix.
skeptic: leave-one-out range -0.50 to -0.29, sign flips 0; without severely affected donors -0.37 (p 0.127, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for KY in oligodendrocytes.

case closed: nothing better to follow up.

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