parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.38 (overall 0.24)	0.38
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in choroid plexus epithelial cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	26 Parkinson's papers of 181	0.57
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 1762

KANSL1 in microglia, braak-0.06 (p 0.874) → +0.12 (p 0.759)receipt 1770
KANSL1 in dopamine neurons, braak-0.23 (p 0.553) → +0.20 (p 0.599)receipt 1771

receipt 1771: KANSL1 in dopamine neurons, braak

power: full sample -0.01 (p 0.956, n 18), 95% CI -0.48 to +0.46. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.01 (p 0.983, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.01 (p 0.962, n 18). could be the mix.
skeptic: leave-one-out range -0.14 to +0.10, sign flips 10; without severely affected donors -0.01 (p 0.956, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for KANSL1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 1770: KANSL1 in microglia, braak

power: full sample -0.04 (p 0.867, n 18), 95% CI -0.50 to +0.43. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.07 (p 0.774, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.07 (p 0.774, n 18). could be the mix.
skeptic: leave-one-out range -0.20 to +0.08, sign flips 3; without severely affected donors -0.04 (p 0.867, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for KANSL1 in microglia.

case closed: nothing better to follow up.

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