parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.37 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in endometrial stromal cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 324	0.85
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 0766

receipt 0774: JAZF1 in dopamine neurons, braak

power: full sample -0.41 (p 0.089, n 18), 95% CI -0.74 to +0.07. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.35 (p 0.156, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.56 (p 0.015, n 18). not the mix.
skeptic: leave-one-out range -0.60 to -0.34, sign flips 0; without severely affected donors -0.41 (p 0.089, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for JAZF1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 0773: JAZF1 in microglia, braak

power: full sample -0.04 (p 0.888, n 18), 95% CI -0.49 to +0.44. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.02 (p 0.949, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.13 (p 0.615, n 18). could be the mix.
skeptic: leave-one-out range -0.17 to +0.07, sign flips 4; without severely affected donors -0.04 (p 0.888, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for JAZF1 in microglia.

case closed: nothing better to follow up.

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