parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in sertoli cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	10 Parkinson's papers of 230	0.69
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 11853

receipt 11861: JAM2 in dopamine neurons, braak

power: full sample +0.03 (p 0.901, n 18), 95% CI -0.44 to +0.49. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.07 (p 0.794, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.07 (p 0.794, n 18). could be the mix.
skeptic: leave-one-out range -0.08 to +0.15, sign flips 6; without severely affected donors +0.03 (p 0.901, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for JAM2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 11860: JAM2 in astrocytes, braak

power: full sample -0.25 (p 0.310, n 18), 95% CI -0.64 to +0.24. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.23 (p 0.355, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.16 (p 0.515, n 18). could be the mix.
skeptic: leave-one-out range -0.40 to -0.14, sign flips 0; without severely affected donors -0.25 (p 0.310, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for JAM2 in astrocytes.

case closed: nothing better to follow up.

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