Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.28 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including microglia; strongest in neutrophils | 0.75 |
| chemistry Open Targets | compounds already reach it: fedratinib hydrochloride, gandotinib, xl-019 +28 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 65 Parkinson's papers of 16,912 | 0.45 |
| pathways Reactome | 39 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 1428
Sealed predictions
- JAK2 in dopamine neurons, braak+0.45 (p 0.227) → +0.22 (p 0.563)receipt 1436
- JAK2 in microglia, braak-0.20 (p 0.601) → -0.77 (p 0.015)receipt 1435
Swarm cases
receipt 1436: JAK2 in dopamine neurons, braak
- power
- full sample +0.35 (p 0.159, n 18), 95% CI -0.14 to +0.70. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.31 (p 0.218, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.25 (p 0.319, n 18). could be the mix.
- skeptic
- leave-one-out range +0.30 to +0.55, sign flips 0; without severely affected donors +0.35 (p 0.159, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for JAK2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 1435: JAK2 in microglia, braak
- power
- full sample -0.43 (p 0.079, n 18), 95% CI -0.74 to +0.05. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.38 (p 0.116, n 18). does not hold up.
- composition
- microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.42 (p 0.084, n 18). could be the mix.
- skeptic
- leave-one-out range -0.50 to -0.34, sign flips 0; without severely affected donors -0.43 (p 0.079, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for JAK2 in microglia.
case closed: nothing better to follow up.
Receipts
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