parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.31 (overall 0.20)	0.31
cell type Human Protein Atlas	cell type enhanced, including oligodendrocyte progenitor cells; strongest in vascular smooth muscle cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	9 Parkinson's papers of 179	0.70
pathways Reactome	5 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 2018

receipt 2025: ITGA8 in dopamine neurons, braak

power: full sample +0.22 (p 0.386, n 18), 95% CI -0.28 to +0.62. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.22 (p 0.379, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.31 (p 0.207, n 18). could be the mix.
skeptic: leave-one-out range +0.10 to +0.34, sign flips 0; without severely affected donors +0.22 (p 0.386, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ITGA8 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2024: ITGA8 in oligodendrocytes, braak

power: full sample -0.13 (p 0.615, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.16 (p 0.538, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.21 (p 0.408, n 18). could be the mix.
skeptic: leave-one-out range -0.26 to -0.00, sign flips 0; without severely affected donors -0.13 (p 0.615, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ITGA8 in oligodendrocytes.

case closed: nothing better to follow up.

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