Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (pancreatic islet cells) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 78 Parkinson's papers of 1,406 | 0.42 |
| pathways Reactome | 4 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6247
Sealed predictions
- IAPP in dopamine neurons, braak+0.79 (p 0.011) → +0.22 (p 0.570)receipt 6253
Swarm cases
receipt 6253: IAPP in dopamine neurons, braak
- power
- full sample +0.46 (p 0.055, n 18), 95% CI -0.01 to +0.76. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.49 (p 0.041, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.46 (p 0.055, n 18). could be the mix.
- skeptic
- leave-one-out range +0.39 to +0.65, sign flips 0; without severely affected donors +0.46 (p 0.055, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for IAPP in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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