Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

HSD17B3

hydroxysteroid 17-beta dehydrogenase 3

translation score 0.56, read 2026-11-01; 2 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas		cell type enriched in oligodendrocytes (79 nCPM)1.00
chemistry
Open Targets		a small-molecule pocket0.60
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		no papers tie it to Parkinson's yet1.00
pathways
Reactome		2 pathways; mostly other0.30
proposal for HSD17B3, translation score 0.56

Knock down and overexpress HSD17B3 in oligodendrocytes; measure a transcriptome-wide state shift (bulk RNA-seq) and α-synuclein uptake and myelin basic protein output under oxidative stress.

Cell type
oligodendrocytes
Direction
Both arms: public data does not say which way helps.
Molecular readout
a transcriptome-wide state shift (bulk RNA-seq)
Functional readout
α-synuclein uptake and myelin basic protein output under oxidative stress
Rule-out
If neither arm moves a transcriptome-wide state shift (bulk RNA-seq) by 20% or more against non-targeting and empty-vector controls, across three independent differentiations, the hypothesis is wrong.
Lab request
CRISPRi knockdown and lentiviral overexpression of HSD17B3 in iPSC-derived oligodendrocytes; n = 3 differentiations; readouts: a transcriptome-wide state shift (bulk RNA-seq); α-synuclein uptake and myelin basic protein output under oxidative stress. Controls: non-targeting guide, empty vector. About 8 to 10 weeks, most of it differentiation.

Sealed predictions

  1. HSD17B3 in dopamine neurons, braakn/a → n/areceipt 16891
  2. HSD17B3 in oligodendrocytes, braakn/a → n/areceipt 16890

Swarm cases

receipt 16891: HSD17B3 in dopamine neurons, braak

cell type
HSD17B3 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HSD17B3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 16890: HSD17B3 in oligodendrocytes, braak

cell type
HSD17B3 is not measured in oligodendrocytes; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HSD17B3 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

loading the receipts