Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

HOXD1

homeobox D1

translation score 0.45, read 2026-10-27; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced, including oligodendrocytes; strongest in epididymal principal cells0.75
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 12077

Sealed predictions

  1. HOXD1 in dopamine neurons, braakn/a → n/areceipt 12085
  2. HOXD1 in oligodendrocytes, braakn/a → n/areceipt 12084

Swarm cases

receipt 12085: HOXD1 in dopamine neurons, braak

cell type
HOXD1 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HOXD1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 12084: HOXD1 in oligodendrocytes, braak

cell type
HOXD1 is not measured in oligodendrocytes; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HOXD1 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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