Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (endometrial stromal cells) | 0.10 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 519 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3604
Sealed predictions
- HOXA11 in dopamine neurons, braak-0.14 (p 0.714) → -0.89 (p 0.001)receipt 3610
Swarm cases
receipt 3610: HOXA11 in dopamine neurons, braak
- power
- full sample -0.50 (p 0.034, n 18), 95% CI -0.78 to -0.04. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.55 (p 0.017, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.64 (p 0.0044, n 18). not the mix.
- skeptic
- leave-one-out range -0.68 to -0.44, sign flips 0; without severely affected donors -0.50 (p 0.034, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HOXA11 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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