Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (extravillous trophoblasts) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.50 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 7 pathways; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 12453
Sealed predictions
- HLA-G in dopamine neurons, braak-0.11 (p 0.787) → +0.33 (p 0.393)receipt 12460
Swarm cases
receipt 12460: HLA-G in dopamine neurons, braak
- power
- full sample -0.03 (p 0.922, n 18), 95% CI -0.49 to +0.45. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.01 (p 0.976, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.03 (p 0.922, n 18). could be the mix.
- skeptic
- leave-one-out range -0.18 to +0.06, sign flips 8; without severely affected donors -0.03 (p 0.922, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HLA-G in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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