Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in goblet cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 14088
Sealed predictions
- HID1 in dopamine neurons, braak+0.04 (p 0.909) → -0.32 (p 0.400)receipt 14097
- HID1 in oligodendrocytes, braak-0.43 (p 0.253) → -0.15 (p 0.697)receipt 14096
Swarm cases
receipt 14097: HID1 in dopamine neurons, braak
- power
- full sample -0.09 (p 0.709, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.06 (p 0.807, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.01 (p 0.983, n 18). could be the mix.
- skeptic
- leave-one-out range -0.27 to +0.01, sign flips 1; without severely affected donors -0.09 (p 0.709, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HID1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 14096: HID1 in oligodendrocytes, braak
- power
- full sample -0.18 (p 0.482, n 18), 95% CI -0.59 to +0.32. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.21 (p 0.408, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.22 (p 0.374, n 18). could be the mix.
- skeptic
- leave-one-out range -0.32 to -0.08, sign flips 0; without severely affected donors -0.18 (p 0.482, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HID1 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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