Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

HAND2

heart and neural crest derivatives expressed 2

translation score 0.34, read 2026-10-28; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced outside the brain (endometrial stromal cells)0.10
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
1 Parkinson's trial, 0 stopped1.00
literature
PubMed
1 Parkinson's papers of 6920.91
pathways
Reactome
2 pathways; mostly other0.30

No case: the score is under the bar. Receipt 13256

Sealed predictions

  1. HAND2 in dopamine neurons, braakn/a → n/areceipt 13263

Swarm cases

receipt 13263: HAND2 in dopamine neurons, braak

cell type
HAND2 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HAND2 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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