Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (pdcs) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 4 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 4 Parkinson's papers of 1,411 | 0.79 |
| pathways Reactome | 4 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 8850
Sealed predictions
- GZMB in dopamine neurons, braak-0.26 (p 0.493) → +0.26 (p 0.493)receipt 8857
Swarm cases
receipt 8857: GZMB in dopamine neurons, braak
- power
- full sample -0.02 (p 0.935, n 18), 95% CI -0.48 to +0.45. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.01 (p 0.983, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.09 (p 0.735, n 18). could be the mix.
- skeptic
- leave-one-out range -0.17 to +0.11, sign flips 6; without severely affected donors -0.02 (p 0.935, n 18). fragile.
- cell type
- strongest in astrocytes: -0.66 (p 0.0028, n 18) vs -0.02 in dopamine neurons. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GZMB in dopamine neurons.
case closed: every proposal failed a challenge.
Receipts
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