Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in retinal amacrine cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 14998
Sealed predictions
- GSG1L in dopamine neurons, braak-0.04 (p 0.928) → -0.47 (p 0.207)receipt 15007
- GSG1L in oligodendrocytes, braak+0.19 (p 0.623) → -0.63 (p 0.068)receipt 15006
Swarm cases
receipt 15007: GSG1L in dopamine neurons, braak
- power
- full sample -0.32 (p 0.191, n 18), 95% CI -0.69 to +0.17. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.33 (p 0.176, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.53 (p 0.024, n 18). not the mix.
- skeptic
- leave-one-out range -0.48 to -0.24, sign flips 0; without severely affected donors -0.32 (p 0.191, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GSG1L in dopamine neurons.
case closed: nothing better to follow up.
receipt 15006: GSG1L in oligodendrocytes, braak
- power
- full sample -0.17 (p 0.498, n 18), 95% CI -0.59 to +0.32. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.19 (p 0.444, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.44 (p 0.069, n 18). could be the mix.
- skeptic
- leave-one-out range -0.28 to -0.05, sign flips 0; without severely affected donors -0.17 (p 0.498, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GSG1L in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
loading the receipts