Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in bergmann glia | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 6 Parkinson's papers of 77 | 0.74 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 5416
Sealed predictions
- GPR37L1 in dopamine neurons, braak+0.16 (p 0.672) → -0.56 (p 0.116)receipt 5425
- GPR37L1 in oligodendrocytes, braak+0.03 (p 0.929) → -0.40 (p 0.285)receipt 5424
Swarm cases
receipt 5425: GPR37L1 in dopamine neurons, braak
- power
- full sample -0.00 (p 0.997, n 18), 95% CI -0.47 to +0.47. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.00 (p 0.997, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.00 (p 0.997, n 18). could be the mix.
- skeptic
- leave-one-out range -0.14 to +0.08, sign flips 10; without severely affected donors -0.00 (p 0.997, n 18). fragile.
- cell type
- strongest in microglia: -0.67 (p 0.0024, n 18) vs -0.00 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GPR37L1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up GPR37L1 · microglia · braak: substantia nigra, an independent cohort (already registered)
receipt 5424: GPR37L1 in oligodendrocytes, braak
- power
- full sample -0.09 (p 0.715, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.08 (p 0.748, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.00 (p 0.990, n 18). could be the mix.
- skeptic
- leave-one-out range -0.25 to +0.04, sign flips 1; without severely affected donors -0.09 (p 0.715, n 18). fragile.
- cell type
- strongest in microglia: -0.67 (p 0.0024, n 18) vs -0.09 in oligodendrocytes. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GPR37L1 in oligodendrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up GPR37L1 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.57 p 0.041 (needs p < 3.7e-4)
Receipts
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