parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.08 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in oligodendrocytes (623 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	11 Parkinson's papers of 273	0.67
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 3488

receipt 3496: GNAO1 in dopamine neurons, braak

power: full sample -0.36 (p 0.142, n 18), 95% CI -0.71 to +0.13. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.34 (p 0.164, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.39 (p 0.105, n 18). could be the mix.
skeptic: leave-one-out range -0.47 to -0.28, sign flips 0; without severely affected donors -0.36 (p 0.142, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for GNAO1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 3495: GNAO1 in oligodendrocytes, braak

power: full sample -0.35 (p 0.156, n 18), 95% CI -0.70 to +0.14. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.30 (p 0.228, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.14 (p 0.585, n 18). could be the mix.
skeptic: leave-one-out range -0.55 to -0.30, sign flips 0; without severely affected donors -0.35 (p 0.156, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for GNAO1 in oligodendrocytes.

case closed: nothing better to follow up.

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