Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (late spermatids) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 3 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 16798
Sealed predictions
- GFRA4 in dopamine neurons, braak-0.31 (p 0.414) → -0.44 (p 0.232)receipt 16805
Swarm cases
receipt 16805: GFRA4 in dopamine neurons, braak
- power
- full sample -0.48 (p 0.044, n 18), 95% CI -0.77 to -0.02. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.46 (p 0.054, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.62 (p 0.0064, n 18). not the mix.
- skeptic
- leave-one-out range -0.65 to -0.42, sign flips 0; without severely affected donors -0.48 (p 0.044, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GFRA4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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