Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

GABRG1

gamma-aminobutyric acid type A receptor subunit gamma1

translation score 0.45, read 2026-10-17; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.30 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including astrocytes; strongest in ependymal cells0.75
chemistry
Open Targets		compounds already reach it: alprazolam, isoflurane, methohexital +681.00
trials
ClinicalTrials.gov		1 Parkinson's trial, 1 stopped0.20
literature
PubMed		no papers tie it to Parkinson's yet1.00
pathways
Reactome		in no curated pathway0.00

No case: the score is under the bar. Receipt 1279

Sealed predictions

  1. GABRG1 in dopamine neurons, braak+0.47 (p 0.202) → +0.20 (p 0.597)receipt 1286
  2. GABRG1 in astrocytes, braak-0.12 (p 0.767) → +0.15 (p 0.705)receipt 1285

Swarm cases

receipt 1286: GABRG1 in dopamine neurons, braak

power
full sample +0.32 (p 0.191, n 18), 95% CI -0.17 to +0.69. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.32 (p 0.201, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.30 (p 0.232, n 18). could be the mix.
skeptic
leave-one-out range +0.24 to +0.51, sign flips 0; without severely affected donors +0.32 (p 0.191, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GABRG1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 1285: GABRG1 in astrocytes, braak

power
full sample +0.02 (p 0.928, n 18), 95% CI -0.45 to +0.48. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.02 (p 0.935, n 18). does not hold up.
composition
astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.08 (p 0.767, n 18). could be the mix.
skeptic
leave-one-out range -0.09 to +0.18, sign flips 8; without severely affected donors +0.02 (p 0.928, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GABRG1 in astrocytes.

case closed: nothing better to follow up.

Receipts

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