parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in oligodendrocytes (1155 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 451	0.91
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 11830

receipt 11838: FUT8 in dopamine neurons, braak

power: full sample +0.35 (p 0.153, n 18), 95% CI -0.14 to +0.70. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.30 (p 0.232, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.47 (p 0.049, n 18). not the mix.
skeptic: leave-one-out range +0.27 to +0.52, sign flips 0; without severely affected donors +0.35 (p 0.153, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for FUT8 in dopamine neurons.

case closed: nothing better to follow up.

receipt 11837: FUT8 in oligodendrocytes, braak

power: full sample +0.22 (p 0.384, n 18), 95% CI -0.28 to +0.62. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.21 (p 0.408, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.25 (p 0.319, n 18). could be the mix.
skeptic: leave-one-out range +0.12 to +0.35, sign flips 0; without severely affected donors +0.22 (p 0.384, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for FUT8 in oligodendrocytes.

case closed: nothing better to follow up.

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