parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in neutrophils	0.75
chemistry Open Targets	hard to drug	0.40
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 14592

FKBP15 in dopamine neurons, braak+0.06 (p 0.886) → +0.05 (p 0.893)receipt 14600
FKBP15 in microglia, braak-0.26 (p 0.502) → +0.27 (p 0.474)receipt 14599

receipt 14600: FKBP15 in dopamine neurons, braak

power: full sample -0.06 (p 0.807, n 18), 95% CI -0.51 to +0.42. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.01 (p 0.969, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.01 (p 0.983, n 18). could be the mix.
skeptic: leave-one-out range -0.22 to +0.05, sign flips 1; without severely affected donors -0.06 (p 0.807, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for FKBP15 in dopamine neurons.

case closed: nothing better to follow up.

receipt 14599: FKBP15 in microglia, braak

power: full sample +0.09 (p 0.709, n 18), 95% CI -0.39 to +0.54. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.11 (p 0.664, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.09 (p 0.722, n 18). could be the mix.
skeptic: leave-one-out range -0.03 to +0.22, sign flips 2; without severely affected donors +0.09 (p 0.709, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for FKBP15 in microglia.

case closed: nothing better to follow up.

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