Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.36 (overall 0.22) | 0.36 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.27 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 24 | 0.85 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 1902
Sealed predictions
- FBRSL1 in dopamine neurons, braak-0.44 (p 0.232) → -0.53 (p 0.138)receipt 1909
Swarm cases
receipt 1909: FBRSL1 in dopamine neurons, braak
- power
- full sample -0.45 (p 0.059, n 18), 95% CI -0.76 to +0.02. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.48 (p 0.042, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.60 (p 0.0083, n 18). not the mix.
- skeptic
- leave-one-out range -0.58 to -0.39, sign flips 0; without severely affected donors -0.45 (p 0.059, n 18). robust.
- cell type
- strongest in microglia: -0.63 (p 0.0051, n 18) vs -0.45 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FBRSL1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up FBRSL1 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.32 p 0.248 (needs p < 8.1e-4)
Receipts
loading the receipts