Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in retinal pigment epithelial cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 14076
Sealed predictions
- FAM221A in dopamine neurons, braak+0.05 (p 0.893) → +0.26 (p 0.493)receipt 14085
- FAM221A in oligodendrocytes, braak-0.21 (p 0.591) → -0.19 (p 0.630)receipt 14084
Swarm cases
receipt 14085: FAM221A in dopamine neurons, braak
- power
- full sample -0.05 (p 0.854, n 18), 95% CI -0.50 to +0.43. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.00 (p 0.997, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.03 (p 0.901, n 18). could be the mix.
- skeptic
- leave-one-out range -0.15 to +0.08, sign flips 4; without severely affected donors -0.05 (p 0.854, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FAM221A in dopamine neurons.
case closed: nothing better to follow up.
receipt 14084: FAM221A in oligodendrocytes, braak
- power
- full sample -0.23 (p 0.360, n 18), 95% CI -0.63 to +0.27. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.23 (p 0.360, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.28 (p 0.254, n 18). could be the mix.
- skeptic
- leave-one-out range -0.41 to -0.12, sign flips 0; without severely affected donors -0.23 (p 0.360, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FAM221A in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
loading the receipts