Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (hepatocytes) | 0.10 |
| chemistry Open Targets | compounds already reach it: eptacog alfa (activated), prothrombin complex concentrate, pci-27483 +2 | 0.90 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 15 Parkinson's papers of 2,476 | 0.64 |
| pathways Reactome | 6 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 13978
Sealed predictions
- F7 in dopamine neurons, braak-0.58 (p 0.102) → -0.29 (p 0.449)receipt 13984
Swarm cases
receipt 13984: F7 in dopamine neurons, braak
- power
- full sample -0.41 (p 0.093, n 18), 95% CI -0.73 to +0.07. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.52 (p 0.026, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.57 (p 0.014, n 18). not the mix.
- skeptic
- leave-one-out range -0.52 to -0.33, sign flips 0; without severely affected donors -0.41 (p 0.093, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for F7 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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