Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.09 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: lasofoxifene tartrate, ospemifene, erteberel +32 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 8 Parkinson's papers of 1,430 | 0.71 |
| pathways Reactome | 6 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 2851
Sealed predictions
- ESR2 in dopamine neurons, braak-0.10 (p 0.805) → +0.26 (p 0.498)receipt 2858
Swarm cases
receipt 2858: ESR2 in dopamine neurons, braak
- power
- full sample +0.18 (p 0.476, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.15 (p 0.544, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.18 (p 0.476, n 18). could be the mix.
- skeptic
- leave-one-out range +0.09 to +0.32, sign flips 0; without severely affected donors +0.18 (p 0.476, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ESR2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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