Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.31 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 3 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 1219
Sealed predictions
- EPS15L1 in dopamine neurons, braak-0.69 (p 0.041) → +0.01 (p 0.982)receipt 1226
Swarm cases
receipt 1226: EPS15L1 in dopamine neurons, braak
- power
- full sample -0.40 (p 0.097, n 18), 95% CI -0.73 to +0.08. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.44 (p 0.067, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.58 (p 0.013, n 18). not the mix.
- skeptic
- leave-one-out range -0.53 to -0.33, sign flips 0; without severely affected donors -0.40 (p 0.097, n 18). robust.
- cell type
- strongest in OPCs: -0.65 (p 0.0037, n 18) vs -0.40 in dopamine neurons. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for EPS15L1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up EPS15L1 · OPCs · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.53 p 0.062 (needs p < 0.0011)
Receipts
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