parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.03 (overall 0.05)	0.03
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in bergmann glia	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 5115

receipt 5123: ENHO in dopamine neurons, braak

power: full sample -0.00 (p 0.997, n 18), 95% CI -0.47 to +0.47. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.01 (p 0.969, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.00 (p 0.997, n 18). could be the mix.
skeptic: leave-one-out range -0.13 to +0.13, sign flips 8; without severely affected donors -0.00 (p 0.997, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ENHO in dopamine neurons.

case closed: nothing better to follow up.

receipt 5122: ENHO in astrocytes, braak

power: full sample -0.29 (p 0.243, n 18), 95% CI -0.67 to +0.20. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.20 (p 0.418, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.12 (p 0.640, n 18). could be the mix.
skeptic: leave-one-out range -0.44 to -0.20, sign flips 0; without severely affected donors -0.29 (p 0.243, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ENHO in astrocytes.

case closed: nothing better to follow up.

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