Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in loop of henle epithelial cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.50 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 163 | 0.91 |
| pathways Reactome | 10 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 13916
Sealed predictions
- DOCK1 in dopamine neurons, braak-0.20 (p 0.604) → -0.48 (p 0.192)receipt 13923
- DOCK1 in oligodendrocytes, braak-0.36 (p 0.336) → -0.04 (p 0.909)receipt 13922
Swarm cases
receipt 13923: DOCK1 in dopamine neurons, braak
- power
- full sample -0.38 (p 0.118, n 18), 95% CI -0.72 to +0.10. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.33 (p 0.176, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.45 (p 0.059, n 18). could be the mix.
- skeptic
- leave-one-out range -0.49 to -0.31, sign flips 0; without severely affected donors -0.38 (p 0.118, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DOCK1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 13922: DOCK1 in oligodendrocytes, braak
- power
- full sample -0.16 (p 0.538, n 18), 95% CI -0.58 to +0.34. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.12 (p 0.640, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.14 (p 0.567, n 18). could be the mix.
- skeptic
- leave-one-out range -0.33 to -0.08, sign flips 0; without severely affected donors -0.16 (p 0.538, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DOCK1 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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