Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 57 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 16553
Sealed predictions
- DIXDC1 in dopamine neurons, braak+0.04 (p 0.924) → +0.32 (p 0.402)receipt 16560
Swarm cases
receipt 16560: DIXDC1 in dopamine neurons, braak
- power
- full sample +0.09 (p 0.715, n 18), 95% CI -0.39 to +0.54. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.11 (p 0.652, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.06 (p 0.820, n 18). could be the mix.
- skeptic
- leave-one-out range +0.00 to +0.26, sign flips 2; without severely affected donors +0.09 (p 0.715, n 18). fragile.
- cell type
- strongest in OPCs: +0.65 (p 0.0037, n 18) vs +0.09 in dopamine neurons. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DIXDC1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up DIXDC1 · OPCs · braak: substantia nigra, an independent cohort: not measured
Receipts
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