Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

DERL3

derlin 3

translation score 0.49, read 2026-10-29; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas
cell type enriched outside the brain (plasma cells)0.10
chemistry
Open Targets
reachable by antibody0.36
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
3 pathways; mostly lysosome and autophagy1.00

No case: the score is under the bar. Receipt 13812

Sealed predictions

  1. DERL3 in dopamine neurons, braakn/a → n/areceipt 13819

Swarm cases

receipt 13819: DERL3 in dopamine neurons, braak

cell type
DERL3 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for DERL3 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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