parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.50 from other evidence	0.00
cell type Human Protein Atlas	group enriched, including astrocytes; strongest in choroid plexus epithelial cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	4 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 0215

DDX39B in astrocytes, braak-0.01 (p 0.981) → -0.34 (p 0.374)receipt 0222
DDX39B in dopamine neurons, braak-0.15 (p 0.697) → +0.36 (p 0.348)receipt 0223

receipt 0223: DDX39B in dopamine neurons, braak

power: full sample +0.09 (p 0.735, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.10 (p 0.702, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.10 (p 0.702, n 18). could be the mix.
skeptic: leave-one-out range -0.03 to +0.22, sign flips 4; without severely affected donors +0.09 (p 0.735, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DDX39B in dopamine neurons.

case closed: nothing better to follow up.

receipt 0222: DDX39B in astrocytes, braak

power: full sample -0.23 (p 0.355, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.16 (p 0.515, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.21 (p 0.403, n 18). could be the mix.
skeptic: leave-one-out range -0.41 to -0.12, sign flips 0; without severely affected donors -0.23 (p 0.355, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DDX39B in astrocytes.

case closed: nothing better to follow up.

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