parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.08 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in microglia (98 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	5 Parkinson's papers of 46	0.76
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 3301

receipt 3310: DAGLB in dopamine neurons, braak

power: full sample -0.11 (p 0.671, n 18), 95% CI -0.55 to +0.38. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.09 (p 0.722, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.08 (p 0.761, n 18). could be the mix.
skeptic: leave-one-out range -0.25 to +0.02, sign flips 1; without severely affected donors -0.11 (p 0.671, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DAGLB in dopamine neurons.

case closed: nothing better to follow up.

receipt 3309: DAGLB in microglia, braak

power: full sample +0.08 (p 0.761, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.07 (p 0.774, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.21 (p 0.413, n 18). could be the mix.
skeptic: leave-one-out range -0.04 to +0.21, sign flips 2; without severely affected donors +0.08 (p 0.761, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DAGLB in microglia.

case closed: nothing better to follow up.

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