Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 193 | 0.91 |
| pathways Reactome | Reactome did not answer (Reactome: HTTP 521) | 0.00 |
No case: the score is under the bar. Receipt 15632
Sealed predictions
- CREB3 in dopamine neurons, braak+0.20 (p 0.613) → -0.21 (p 0.591)receipt 15638
Swarm cases
receipt 15638: CREB3 in dopamine neurons, braak
- power
- full sample +0.01 (p 0.956, n 18), 95% CI -0.46 to +0.48. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.00 (p 0.990, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.05 (p 0.847, n 18). could be the mix.
- skeptic
- leave-one-out range -0.10 to +0.14, sign flips 6; without severely affected donors +0.01 (p 0.956, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CREB3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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