Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in sertoli cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.27 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 4 Parkinson's papers of 23 | 0.79 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 13467
Sealed predictions
- CPNE5 in dopamine neurons, braak-0.51 (p 0.160) → -0.36 (p 0.336)receipt 13474
Swarm cases
receipt 13474: CPNE5 in dopamine neurons, braak
- power
- full sample -0.40 (p 0.103, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.42 (p 0.080, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.52 (p 0.027, n 18). not the mix.
- skeptic
- leave-one-out range -0.50 to -0.32, sign flips 0; without severely affected donors -0.40 (p 0.103, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CPNE5 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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