Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in endometrial ciliated cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 14312
Sealed predictions
- CHST6 in oligodendrocytes, braak-0.40 (p 0.285) → +0.50 (p 0.174)receipt 14319
- CHST6 in dopamine neurons, braak+0.33 (p 0.387) → -0.22 (p 0.565)receipt 14320
Swarm cases
receipt 14320: CHST6 in dopamine neurons, braak
- power
- full sample +0.07 (p 0.787, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.11 (p 0.664, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.13 (p 0.615, n 18). could be the mix.
- skeptic
- leave-one-out range -0.07 to +0.21, sign flips 2; without severely affected donors +0.07 (p 0.787, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CHST6 in dopamine neurons.
case closed: nothing better to follow up.
receipt 14319: CHST6 in oligodendrocytes, braak
- power
- full sample -0.03 (p 0.901, n 18), 95% CI -0.49 to +0.44. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.12 (p 0.627, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.33 (p 0.185, n 18). could be the mix.
- skeptic
- leave-one-out range -0.17 to +0.11, sign flips 4; without severely affected donors -0.03 (p 0.901, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CHST6 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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