Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including astrocytes; strongest in late primary spermatocytes | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 8623
Sealed predictions
- CHST1 in dopamine neurons, braak-0.56 (p 0.116) → -0.82 (p 0.007)receipt 8630
- CHST1 in astrocytes, braak-0.32 (p 0.407) → +0.19 (p 0.631)receipt 8629
Swarm cases
receipt 8630: CHST1 in dopamine neurons, braak
- power
- full sample -0.63 (p 0.0051, n 18), 95% CI -0.85 to -0.23. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.69 (p 0.0014, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.80 (p 7.5e-5, n 18). not the mix.
- skeptic
- leave-one-out range -0.73 to -0.58, sign flips 0; without severely affected donors -0.63 (p 0.0051, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CHST1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 8629: CHST1 in astrocytes, braak
- power
- full sample +0.11 (p 0.664, n 18), 95% CI -0.38 to +0.55. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.15 (p 0.555, n 18). does not hold up.
- composition
- astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.15 (p 0.555, n 18). could be the mix.
- skeptic
- leave-one-out range -0.01 to +0.22, sign flips 3; without severely affected donors +0.11 (p 0.664, n 18). fragile.
- cell type
- strongest in dopamine neurons: -0.63 (p 0.0051, n 18) vs +0.11 in astrocytes. proposing dopamine neurons.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CHST1 in astrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up CHST1 · dopamine neurons · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.15 p 0.594 (needs p < 2.5e-4)
Receipts
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