Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 50 | 0.91 |
| pathways Reactome | 7 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 15732
Sealed predictions
- CEP131 in dopamine neurons, braak-0.15 (p 0.702) → -0.08 (p 0.840)receipt 15740
Swarm cases
receipt 15740: CEP131 in dopamine neurons, braak
- power
- full sample -0.08 (p 0.754, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.09 (p 0.735, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.07 (p 0.774, n 18). could be the mix.
- skeptic
- leave-one-out range -0.16 to +0.04, sign flips 4; without severely affected donors -0.08 (p 0.754, n 18). fragile.
- cell type
- strongest in oligodendrocytes: -0.69 (p 0.0016, n 18) vs -0.08 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CEP131 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up CEP131 · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.82 p 0.0034 (needs p < 1.5e-4)
Receipts
loading the receipts