Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including astrocytes; strongest in retinal amacrine cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 14409
Sealed predictions
- CDH24 in astrocytes, braak-0.04 (p 0.928) → +0.53 (p 0.145)receipt 14416
- CDH24 in dopamine neurons, braak-0.75 (p 0.021) → -0.16 (p 0.685)receipt 14417
Swarm cases
receipt 14417: CDH24 in dopamine neurons, braak
- power
- full sample -0.47 (p 0.047, n 18), 95% CI -0.77 to -0.01. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.47 (p 0.047, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.77 (p 2.1e-4, n 18). not the mix.
- skeptic
- leave-one-out range -0.61 to -0.41, sign flips 0; without severely affected donors -0.47 (p 0.047, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CDH24 in dopamine neurons.
case closed: nothing better to follow up.
receipt 14416: CDH24 in astrocytes, braak
- power
- full sample +0.18 (p 0.471, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.18 (p 0.465, n 18). does not hold up.
- composition
- astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.16 (p 0.532, n 18). could be the mix.
- skeptic
- leave-one-out range +0.08 to +0.34, sign flips 0; without severely affected donors +0.18 (p 0.471, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CDH24 in astrocytes.
case closed: nothing better to follow up.
Receipts
loading the receipts