Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in other brain neurons (114 nCPM) | 1.00 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 4 Parkinson's papers of 159 | 0.79 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 4602
Sealed predictions
- CALB2 in dopamine neurons, braak-0.23 (p 0.555) → +0.65 (p 0.057)receipt 4609
Swarm cases
receipt 4609: CALB2 in dopamine neurons, braak
- power
- full sample +0.26 (p 0.306, n 18), 95% CI -0.24 to +0.65. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.24 (p 0.328, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.19 (p 0.455, n 18). could be the mix.
- skeptic
- leave-one-out range +0.15 to +0.41, sign flips 0; without severely affected donors +0.26 (p 0.306, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CALB2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts