parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in choroid plexus epithelial cells	0.75
chemistry Open Targets	reachable by antibody	0.36
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 16159

CACHD1 in astrocytes, braak+0.11 (p 0.785) → +0.27 (p 0.487)receipt 16167
CACHD1 in dopamine neurons, braak+0.11 (p 0.787) → +0.20 (p 0.597)receipt 16168

receipt 16168: CACHD1 in dopamine neurons, braak

power: full sample +0.23 (p 0.369, n 18), 95% CI -0.27 to +0.63. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.23 (p 0.369, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.21 (p 0.393, n 18). could be the mix.
skeptic: leave-one-out range +0.11 to +0.32, sign flips 0; without severely affected donors +0.23 (p 0.369, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CACHD1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 16167: CACHD1 in astrocytes, braak

power: full sample +0.19 (p 0.444, n 18), 95% CI -0.30 to +0.60. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.19 (p 0.455, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.17 (p 0.493, n 18). could be the mix.
skeptic: leave-one-out range +0.07 to +0.30, sign flips 0; without severely affected donors +0.19 (p 0.444, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CACHD1 in astrocytes.

case closed: nothing better to follow up.

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